Chemical biology approaches to confirm the druggability of neurodegeneration linked rhomboid proteases. KU Leuven
Alzheimer’s disease and Parkinson´s disease belong to a group of illnesses that cause the progressive loss of function of neurons, which leads to dementia as most common symptom. These diseases are a puzzle from which we still lack many pieces. As a result, no drug targets for these diseases are known and no cure exists. One of the missing parts of the puzzle may be a group of proteins called rhomboids. Rhomboids are found in all living ...