Projects
Fishing for regulators of neuronal repair in the degenerating central nervous system of the fast-aging Killifish KU Leuven
Neurodegenerative diseases associated with aging show an
increasing prevalence in our greying society. As adult mammals lack
the robust capacity to regenerate lost or damaged neurons, agerelated
deterioration of the central nervous system (CNS) seriously
constrains life quality and overall wellbeing of our elderly population.
In contrast to mammals, short-lived killifish, which show aging
characteristics similar ...
Timed dendrite-axon routing of mitochondria enables successful repair in the injured central nervous system KU Leuven
Neural insults and neurodegenerative diseases typically result in permanent functional deficits and represent a growing social and economic problem in our aging society. As the central nervous system of adult mammals only has a limited regenerative capacity, identifying cellular and molecular mechanisms that enable neuronal regeneration forms a critical step towards designing future pro-regenerative therapies. Within this project we aim to ...
The role of A20/NF-kB pathway in the development of neuroinflammation in the central nervous system in neuropsychiatric systemic lupus erythematosus and schizophrenia KU Leuven
The proposed project comprises 3 objectives with the ultimate aim to gain more insight into the role of A20/NF-kB signal transduction in neuroinflammation in patients with NPSLE.
ElecXite: Molecular and Cellular Mechanisms of Electrical Excitability in the Heart and Central Nervous System Hasselt University
Characterization of immune responses against allogeneic stem cell implants in the central nervous system. University of Antwerp
Intraneuronal shift in bioenergetics as key for neuronal repair in the central nervous system KU Leuven
Brain injury and neurodegenerative disorders represent a growing socio-economic problem in our aging society, partly because the central nervous system (CNS) of mammals has a limited regenerative capacity. Most of the injured neurons die, and the few survivors fail to extend their axons beyond the damaged site. Despite many years of research, functional circuit regeneration is still not possible. Up till now, the contribution of dendrites to ...