Projects
Deficiency and toxicity of micronutrients (copper and zinc): the reducing potential as a driving force in plant responses (Arabidopsis thaliana and Brassica oleracea) Hasselt University
Metal Mixture Toxicity and Defense Mechanism in Zebra fish (Danio rerio) and other Model Species. Hasselt University
Modulatory toxicity effects of metal mixtures on chemosensation and behavior. University of Antwerp
Aluminum toxicity in plants, understanding responses to aluminum in sensitive and tolerant rye genotypes University of Antwerp
Creation of an Adverse Outcome Pathway (AOP) for Cd, Cu and Zn mixture toxicity on Arabidopsis roots. University of Antwerp
Targeting Polo-like kinase 1 for treatment of NSCLC patients: focus on the induction of cellular senescence, the TP53 status and hypoxia. University of Antwerp
Establishment of a vehicle-cargo system to boost cellular export in industrial biotechnology Ghent University
Microorganisms are extensively genetically modified in order to produce useful compounds they do not produce by nature and these are in general assembled inside the cell.
However, often problems are encountered regarding product toxicity and limited export. We will develop a vehicle-cargo system offering solutions here; a re-usable vehicle helps the cargo (molecule of interest) to reach the outside space.
The role of organelle contact sites in Parkinson’s disease-associated α-synuclein toxicity: insights from a yeast model KU Leuven
This PhD project aimed to identify novel players involved in α-syn toxicity, with a particular focus on those involved in inter-organelle communication. The general goal was to elucidate the molecular mechanisms that underlie α-syn toxicity and uncover the role of MCSs in this process. The first experimental part of this study was dedicated to identifying MCS deletion mutants involved in mediating α-syn toxicity. In order to achieve this, we ...