Unraveling molecular pathways underlying synergistic cellular toxicity of Aß peptides and protein Tau, the two key players involved in Alzheimer’s disease. KU Leuven
Alzheimers’s Disease (AD) is the most common neurodegenerative disorder. Today, more than 35 million people are suffering from dementia such as AD, a number that has been estimated to double every 20 years. Brains from AD patients have two major hallmarks. They contain intracellular deposits of hyperphosphorylated protein Tau, known as neurofibrillary tangles as well as extracellular deposits of Aß peptides, known as amyloid plaques. Despite ...