Identification of the Ca2+-transport systems and mechanisms contributing to the cell death of cancer B cells upon disruption of IP3R/Bcl-2 complexes KU Leuven
An important part of Bcl-2’s function in cancer cells is to prevent the occurrence of “toxic” Ca2+- release events from the endoplasmic reticulum (ER), the main intracellular Ca2+ store. These Ca2+- release events are mediated by the IP3 receptor, a major class of intracellular Ca2+-release channels in close contact with the mitochondria, the main apoptosis executioner organelle. Hence, inhibiting Bcl-2’s function at the level of the ER using ...