Projects
Characterisation of allergen-induced T cells from healthy individuals KU Leuven
Characterization and processing of Peruvian chili peppers KU Leuven
Chili peppers are consumed not only in Peru but also worldwide, mostly due to their unique sensorial attributes, as well as their nutritional and health benefits. In Peruvian cuisine and cultural traditions, chili peppers play a key role and are consumed on a daily basis. Native chili peppers comprise more than 200 landraces grown in different Peruvian regions. These native landraces, originating from Capsicum genus, differ greatly ...
Large scale genetic approach for molecular characterization of autosomal-recessive Charcot-Marie-Tooth neuropathy. University of Antwerp
Stem Cell and Stromal Vascular Fraction Treatment for Penile Tunica Albuginea and Urethral Fibrosis KU Leuven
Fibrosis is a wound healing disorder and it is defined by the excessive accumulation of fibrous connective tissue, such as collagen and fibronectin, in and around inflamed or damaged tissue. Although collagen and fibronectin deposition is an indispensable and, typically, reversible part of wound healing, normal tissue repair can evolve into a progressively irreversible fibrotic response if the tissue injury is severe or repetitive or if the ...
Aluminium Oxide as Negatively Charged Surface Passivation for Industrial Crystalline Silicon Solar Cells KU Leuven
Exploiting the “dark matter” of the genome to defeat melanoma KU Leuven
The 5-year survival rates of patients with metastatic melanoma are still about 30%. The major reason for the low survival rate of melanoma patients is intrinsic and acquired resistance to the existing therapies. It is therefore essential to develop new therapeutic strategies that will help eradicating resistant cells. By single-cell RNA sequencing of BRAF mutant patient-derived xenograft (PDX) melanoma models analysis we obtained the lncRNA ...
Modeling Renal Fibrosis in Zebrafish Using Aristolochic Acid I KU Leuven
Chronic kidney disease (CKD) is a major global health problem that is characterized by a slow and progressive loss of kidney function. The endpoint of virtually all progressive renal diseases is fibrosis, characterized histologically by an excessive accumulation and deposition of extracellular matrix (ECM) disrupting the normal histo-architecture of the organ.
The number of renal fibrosis patients doubled from 1990 to 2016 making it ...
iPSC Technology and Bone Regeneration KU Leuven
Bone is a calcified tissue with multiple functions. It allows movement by providing attachment points for skeletal muscle, supports haematopoiesis, stores minerals and protects soft tissues and organs. Additionally, bone has the unique capacity to regenerate upon damage without scar formation or loss of function.
Bone fracture repair recapitulates embryonic endochondral bone formation. This process is characterized by the formation of a ...
Local and systemic immune interactions in malignant gliomas KU Leuven
Glioblastoma (GBM), the most frequent primary intrinsic brain tumor, is without any doubt one of the most devastating diseases known to mankind. GBM are currently being treated with neurosurgical resection followed by radio- and chemotherapy. However, despite this treatment, prognosis for these patients is grim with a median survival of only 15 months and less than 20% 3-year survival rates. Already at diagnosis, GBM cells are infiltrating ...