Generation of chimeric antigen receptor expressing, T cell receptor negative CD4 helper and CD8 cytotoxic cells starting from cord blood hematopoietic precursor cells that are optimized for in vivo tumor eradication.
Generation of tumor-specific, single receptor CD4 helper and CDS cytotoxic cells from cord blood hematopoietic stem cells transgenic for a chimeric antigen receptor (CAR) incorporating a cytoplasmic costimulator domain
Actions required to secure the large-scale deployment of the leading CDR approaches to meet EU climate targets
A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice
Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway
Functionally mature CD4 and CD8 TCRαβ cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells
Notch induces T cell receptor gamma delta thymocytes to differentiate along a bipotent CD4 CD8 double positive pathway
CD4 and CD8 TCR alpha beta cells are selected on MHC expressed on thymocyte precursors in OP9-DL1 cultures
Replication Data for: Algorithmic Differentiation for adjoint sensitivity calculation in plasma edge codes