Publications
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A national cohort of HIV-infected patients in Belgium: design and main characteristics Institute of Tropical Medicine
Proposal to adjust the WHO clinical staging system [letter] Institute of Tropical Medicine
Reducing mortality from HIV infection and tuberculosis [comment] Institute of Tropical Medicine
Prevention of mother-to-child transmission of HIV and the health-related Millennium Development Goals: time for a public health approach [viewpoint] Institute of Tropical Medicine
Mycobacterium ulcerans triggers T cell immunity followed by local and regional but not systemic immunosuppression Institute of Tropical Medicine
Buruli ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans, characterized by necrotic cutaneous lesions induced by the exotoxin mycolactone. Despite evidence of Th1-mediated protective immunity, M. ulcerans infection has been associated with systemic immunosuppression. We show that early during mouse infection with either mycolactone-positive or negative strains, pathogen-specific IFN-gamma-producing T cells developed ...
Evaluation of paradoxical TB-associated IRIS with the use of standardized case definitions for resource-limited settings Institute of Tropical Medicine
OBJECTIVE: Standardized case definitions have recently been proposed by the International Network for the Study of HIV-associated immune reconstitution inflammatory syndrome (INSHI; [IRIS]) for use in resource-limited settings. We evaluated paradoxical tuberculosis (TB)-associated IRIS in a large cohort from a TB endemic setting with the use of these case definitions.
DESIGN: A retrospective cohort study.
METHOD: We reviewed ...