Projects
Cardiovascular and muscle-specific "targeting" for gene therapy of neuromuscular disorders Vrije Universiteit Brussel
High-frequency ultrasound device for the non-invasive study of cardiac and arterial function in mice with genetically determined cardiovascular disorders Ghent University
The requested device is advanced ultrasound equipment which allows to sequentially study, in a non-invasive way and with great precision, the cardiac and arterial function in mice. The equipment with in particular be used in our research on the origin and progression of aortic pathologies (aortic aneurysms and disections) in mouse models of genetically determined cardiovascular pathologies
Small-molecule ERBB4 agonists to treat cardiovascular disorders. University of Antwerp
Study of the molecular background and pathophysiology of monogenic disorders with structural cardiovasuclar anomalies Ghent University
The development and homeostasis of the cardiovascular system is studied in 3 subprojects:
1) Creation and etiopathogenetic study of slc2a10 and gulo double knockout mice and slc2a10 knockout zebrafish as models for arterial tortuosity syndrome.
2) Exome sequencing in rare elastinopathies without known genetic defect
3) Evaluation of somatic mozaicism and de novo mutations underlying congenital cardiopathies ...
Genome medicine for bleeding, thrombotic and platelet disorders KU Leuven
Home-based interventions to increase physical activity in patients with cardiovascular disease KU Leuven
The changing demographics and deteriorating lifestyle of our era result in an increase in the occurrence of cardiovascular disease, which is neither economically or socially sustainable. Exercise is a cornerstone in the therapy of cardiovascular disease, since a more physically active lifestyle results in a decrease in cardiovascular morbidity and mortality.
Center-based cardiovascular rehabilitation is well-implemented in Belgium, ...
Physical activity, physical fitness and cardiovascular risk factors in Suriname KU Leuven
Cardiovascular mortality is the number one cause of death in Suriname, a middle income country in South America. There is an urgent need for interventions targeting the different underlying cardiovascular risk factors in the combat of this rising epidemic. However, data on the distribution of cardiovascular risk factors in this multi-ethnic population of Suriname are scarce. In a cross-sectional observational study we will first collect ...
Computational Time Series Analysis for Cardiovascular Health and Cardiopulmonary Fitness Profiling KU Leuven
To date, there is an unmet need for accurate computational models that can identify and manage individuals at high risk of developing adverse Cardiovascular (CV) events. The purpose of this doctoral project, is the utilization of machine and deep learning algorithms to create a computational pipeline to construct a profile of patients related to their CV health and fitness and predict their response to potential exercise treatment programmes. ...