Projects
Overcoming intrinsic and acquired resistance to EGFR-targeting agents in cancer treatment: focus on identification of predictive biomarkers and novel therapeutic strategies. University of Antwerp
Benchmarking singlet oxygen-based photoelectrochemical detection platform for panel analysis of cancer biomarkers, using prostate cancer as a case study. A novel groundbreaking approach for cancer diagnosis and follow-up. University of Antwerp
EXPLORING AGEING-RELATED BIOMARKERS IN INDIVIDUALS WITH BREAST CANCER AND WITHOUT CANCER KU Leuven
In recent years, it has been increasingly recognized that different persons undergo the ageing process at different rates. Although chronological age has traditionally served as a measure of ageing, it only provides a one-dimensional view. We now know that age-related diseases or conditions independently contribute to unfavorable outcomes and hasten the ageing process, resulting in a wide range of biological ageing rates. The use of ...
‘Cancer in Pregnancy’: Effects of prenatal exposure to cancer treatment on IUGR. To examine the potential biomarkers to develop insights in the underlying pathophysiologic mechanisms of IUGR. KU Leuven
The current prevalence of cancer during pregnancy in Europe is 1 in 1000 to 2000 pregnancies, and this number is increasing. The primordial concern when treating cancer during pregnancy is the potential effect of chemo/radiotherapy on the fetal. In a recent pioneering study on 70 children with prenatal exposure to cancer treatment, Amant et al. found the developmental outcome of such children to be overall reassuring. However, intra-uterine ...
ORDECA – ORganoid Drug screening for Endometrial CAncerIdentifying novel drugs and biomarkers for treating endometrial cancer using a high-throughput patient-derived organoid drug discovery and screening platform KU Leuven
Multi-omics approach to identify pancreatic cancer biomarkers in liquid biopsies of advanced stage patients by pioneering single cell mass spectrometry of CTCs and (epi)genetics characterization of cfDNA Ghent University
Pancreatic cancer is a deadly disease with surgery the only chance for cure. Surgeons have to evaluate whether patients with advanced pancreatic cancer will benefit from surgery. Current diagnostic tools (imaging and CA19-9), are inadequate, with early recurrence and metastases seen in up to 40% of patients. To address this, a multi-omics approach is proposed to identify PDAC biomarkers in liquid biopsies with higher accuracy, sensitivity, ...
Development and validation of electrochemical immunosensors for cervical cancer biomarkers (p16INK4a and Ki-67) detection in cervical and vaginal samples Ghent University
A new photoelectrochemical singlet oxygen-based detection platform for a panel of cancer biomarkers in tissue and liquid biopsies (SOCAN) Ghent University
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. SOCAN will contribute to the (early) diagnosis and follow up of cancer via a new detection paradigm, i.e. singlet oxygen-based photoelectrochemical detection of cancer biomarkers. Those biomarkers are increasingly discovered and validated, but the detection necessitates rapid, accurate and sensitive devices. To achieve this, the combined use of ...