In vivo analysis of the role of a newly identified screenings hit in breast epithelial homeostasis and basal breast cancer progression Ghent University
The hit was identified in an siRNA screen as being crucial in ZEB-1 mediated EMT. Transcription factors essential in normal development play an important role in this process. Moreover, studies have shown that EMT is linked with (cancer)stem cells. This suggests an important function for our hit in normal breast development and the progression of basal breast cancer.