The brainstem and its interaction with the basal ganglia in Parkinson’s Disease: insights from combining invasive and non-invasive human neurophysiology KU Leuven
Deep brain stimulation (DBS) is routinely used to treat Parkinson's disease (PD) symptoms when medication is no longer sufficient. Despite decades of clinical practice, the physiological mechanism underlying DBS remains elusive and it fails to treat a range of gait-related symptoms. Research has mostly focused on the cortico-basal ganglia model but this has proven incomplete. Far less explored is the role of the brainstem nuclei connected to ...