Publications
Double NF1 inactivation affects adrenocortical function in NF1Prx1 mice and a human patient Vrije Universiteit Brussel
BACKGROUND: Neurofibromatosis type I (NF1, MIM#162200) is a relatively frequent genetic condition, which predisposes to tumor formation. Apart from tumors, individuals with NF1 often exhibit endocrine abnormalities such as precocious puberty (2,5-5% of NF1 patients) and some cases of hypertension (16% of NF1 patients). Several cases of adrenal cortex adenomas have been described in NF1 individuals supporting the notion that neurofibromin ...
Guidelines for time-to-event end point definitions in breast cancer trials: results of the DATECAN initiative (Definition for the Assessment of Time-to-event Endpoints in CANcer trials) University of Antwerp KU Leuven
Non Parametric Granger Causality EEG Analysis of a Visual 1-Back-Matching Discrimination Task in Children KU Leuven
Effects of aging and dual tasking on step adjustments to perturbations in visually cued walking KU Leuven
Measuring teaching through hormones and time series analysis: Towards a comparative framework Vrije Universiteit Brussel
Pharmacological characterization of an antisense knockdown zebrafish model of dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine KU Leuven University of Antwerp
Distinct and simultaneously active plasticity mechanisms in mouse hippocampus during different phases of Morris water maze training Vrije Universiteit Brussel KU Leuven
Although the Morris water maze (MWM) is the most frequently used protocol to examine hippocampus-dependent learning in mice, not much is known about the spatio-temporal dynamics of underlying plasticity processes. Here, we studied molecular and cellular hippocampal plasticity mechanisms during early and late phases of spatial learning in the MWM. Quantitative in situ hybridization for the immediate early genes zif268 and Homer1a (H1a) ...
Tissue clearing for confocal imaging of native and bio-artificial skeletal muscle Vrije Universiteit Brussel KU Leuven
Novel clearing techniques have revolutionized three-dimensional confocal imaging of the brain without the need for physical tissue sectioning. We evaluated three clearing methods, ScaleA2, Clear(T2), and 3DISCO for visualizing native and tissue engineered muscle by confocal microscopy. We found that Clear(T2) treatment improved the depth of visualization of immunohistochemical staining slightly, but did not improve depth of visualization of ...