Aging and brain plasticity: alterations in brain structure, function and connectivity in relation to complex motor behavior. KU Leuven
Ageing and brain plasticity. Training-induced alterations in spectral power of the brain and motor coordination KU Leuven
Declines in sensorimotor and cognitive function are well-known consequences of ageing. Improving our understanding of what ageing entails at cellular up to systemic levels is hence timely and urgent. And, finding strategies to decelerate or even reverse the pervasive effects of aging can have a major societal impact. The aim of this thesis was to investigate changes in spectral dynamics of the brain associated with bimanual task difficulty, ...
Extracellular vesicle (EV) transport across the brain barriers: from mechanistic and biological insights towards strategies for delivery of therapeutics to the brain. Ghent University
Extracellular vesicles (EVs) are nanosized membrane vesicles released by a broad range of cells. We study the mechanism by which EVs cross the central nervous system (CNS) barriers using innovative EV-loading technologies and surface proteome analysis. Next, we use this knowledge to develop novel brain targeting strategies for drug delivery.
Modulation of Memory-Related Brain Networks with Non-Invasive Brain Stimulation: A Multimodal Neuroimaging Investigation KU Leuven
Brain plasticity for healthy aging: enhancing motor, and cognitive functions by motor training and noninvasive brain stimulation (NIBS). Hasselt University
The human dog: a translational neurobiological brain model on the molecular effects of the noninvasive brain stimulation technique accelerated high frequency repetitive transcranial magnetic stimulation (HF rTMS) Ghent University
This proposal aims to investigate the neurobiological underpinnings of NIBS treatment modalities for psychiatric diseases. Despite its acceptance as therapy for major depression, the neurobiological basis and effective stimulation parameters are barely known. The main objective is to gain better insight into the immediate and delayed neurobiological effects and safety of 2 HF-rTMS paradigms with the dog as model.
Development of novel imaging tracers for proteolitic remodelling of the brain extracellular matrix following traumatic brain injury University of Antwerp
Field potentials and behavior analysis in rat models of abnormal brain cavities and compulsion KU Leuven
Brain damage is caused by loss or deterioration of brain cells and it is a prevalent type of injury that may be fatal, or may result in severe impairments, with devastating consequences on the quality of life of survivors. Loss of neural cells may lead to the formation of abnormal brain cavities (aBC), that are most often the result of stroke and traumatic brain injuries (TBI), but can also occur after surgical resection of tumors or ...