Publications

Presurgical planning for brain tumor resection aims at delineating eloquent tissue in the vicinity of the lesion to spare during surgery. To this end, noninvasive neuroimaging techniques such as functional MRI and diffusion-weighted imaging fiber tracking are currently employed. However, taking into account this information is often still insufficient, as the complex nonlinear dynamics of the brain impede straightforward prediction of functional ...

Brain tumor patients scheduled for tumor resection often face significant uncertainty, as the outcome of neurosurgery is difficult to predict at the individual patient level. Recently, simulation of the activity of neural populations connected according to the white matter fibers, producing personalized brain network models, has been introduced as a promising tool for this purpose. The Virtual Brain provides a robust open source framework to ...

Mechanical characteristics of tumor and healthy tissue in the brain differ but slightly. The task of designing a system that is able to differentiate tissue dignity with high sensitivity is of great importance in neurosurgery. Even when localization of tumor by use of preoperative imaging techniques provides the surgeon with valuable information to decide where and what to resect, the brain shift due to change in pressure during skull opening ...

Simple Summary The creation of stable fluorescent glioma cell lines opens prospects for the detailed characterization of the molecular mechanisms of glioma origin and pathogenesis, and the development of breakthrough therapeutic approaches to achieve maximum glioma destruction and minimize the risk of future metastases. Herein, we generated and characterized a novel fluorescent glioma GL261-kat cell line stably expressing a far-red fluorescent ...

Background and Importance: We report on a rare case of spontaneous cerebral herniation through a subdural membrane in a 54-year-old patient. Brain herniation in adults as a complication of chronic subdural hematomas shortly after a neurosurgical intervention is rare. We are the first to report a case of delayed local herniation in an adult patient more than 1 year after a neurosurgical procedure. Clinical Presentation: The patient suffered from ...

Radiotherapy (RT) plays a crucial role in the treatment of many primary brain and skull base tumours, including meningioma and low-grade glioma. Due to the nature of the tumours, and the increasing effectiveness of the treatment, long-term survival can be achieved in an increasing number of patients, making side effects an important issue in the follow-up and social reintegration of these patients. Post-RT neurocognitive decline is one of the ...

The mortality rate of brain cancer is one of the highest next to lung cancer. Unfortunately, for brain cancer there are no well-established preventive procedures to avoid risk factors. The surgical procedure to remove (i.e. resection) maligant brain tumours is a critical task that requires from a surgeon well-trained skills to perform with high precision the evaluation of the brain tissue during the operation. Additionally, during skull opening, ...

© Springer Nature Switzerland AG 2019. Automatic brain tumor segmentation plays an important role for diagnosis, surgical planning and treatment assessment of brain tumors. Deep convolutional neural networks (CNNs) have been widely used for this task. Due to the relatively small data set for training, data augmentation at training time has been commonly used for better performance of CNNs. Recent works also demonstrated the usefulness of data ...