The black box of pregnancy first steps: decrypting embryo-endometrium interaction using cutting-edge blastocyst and endometrium models KU Leuven
The first steps in human pregnancy remain a black box since occurring hidden in the womb. Once fertilized, the egg develops into a blastocyst that precisely interacts with the uterus’ inner lining (endometrium) to implant and further develop. This prime embryo-endometrium interaction is critical for successful pregnancy. Our understanding, however, is very limited, mainly because of in vivo inaccessibility and lack of appropriate in vitro ...