Projects

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Valorizing the SymBody Platform for Ultra-stable Biopharmaceuticals through an EIC Pathfinder Open project application. KU Leuven

Arnout Voet
Biochemistry, Molecular and Structural Biology
In a therapeutic setting, conventional antibodies are restricted to delivery through intravenous or subcutaneous injections. Consequently, systemic availability causes many side effects and impedes treatment sustainability because of elicited anti-drug immune responses. Their sub-optimal stability also results in the necessity for cold-chain production and distribution, presenting significant logistical challenges. Conversely, their ...

Addressing the need for increased analytical capacity for biopharmaceuticals and forensic toxicology through automated sample preparation. Ghent University

Dieter Deforce
Department of Pharmaceutics

Flanders, known as Pharma Valley, ranks first globally in the number of drugs in clinical developmen t per capita. Especially biotechnological drug development is gaining a lot of importance herein . Consequentially, t he demand for advanced analytical workflows to characterize the production of biological drugs and assess pharmacokinetics has significantly increased. Current analytical methods involve costly instrumentation and expertise, ...

Flow imaging microscope for advanced analysis of biopharmaceuticals and biological samples Ghent University

Hristo Svilenov
Department of Pharmaceutics, Department of Biochemistry and microbiology

For various reasons, microscopic particles (1-100 µm) can form in protein, nucleic-acid or cell-based medicines. Such particles (such as aggregated proteins) can be very dangerous and, among other things, provoke very severe immunological side reactions in patients. Therefore, the design and development of biopharmaceuticals require careful analysis/understanding of the origin of these particles. Flow imaging microscopy (FIM) is an essential ...

Biopharmaceutical optimization of PET-diagnostic tools targeting fibroblast activation protein (FAP). University of Antwerp

Pieter Van Der Veken
Molecular Imaging and Radiology (MIRA), Medical Biochemistry, Medicinal Chemistry (UAMC)
Fibroblast activation protein (FAP) is a serine type protease that is expressed on stromal cells of > 90% of all epithelial cancer types, and also in pathological lesions associated with other diseases characterized by tissue remodeling. It is virtually absent in healthy adult tissues. FAP is being studied both as a therapeutic target and a biomarker/diagnostics target: not only in oncology, but also in, e.g., different fibrosis types and ...

IOF Proof of Concept: Realizing a chromatography-mass spectrometry expert facility for protein characterization in support of the biopharmaceutical sector Vrije Universiteit Brussel

Sebastiaan Eeltink
Chemical Engineering and Industrial Chemistry
The characterization of protein aggregation, conformation, and chemical identity of proteins represents a major analytical challenge in the pharmaceutical industry. This project is directed at establishing an LC-MS research facility offering hands-on experience and advanced solutions for protein characterization.

Preclinical characterization and biopharmaceutical optimization of the autophagy inhibitor UAMC-2526 for oncotherapy. University of Antwerp

Pieter Van Der Veken
Center for Oncological Research (CORE), Molecular Imaging and Radiology (MIRA), Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO), Physiopharmacology (PHYSPHAR), Medicinal Chemistry (UAMC)
Three UAntwerp research groups (Medicinal Chemistry, Physiopharmacology, MIPRO) recently joined forces for the discovery and study of autophagy modulators as potential oncology therapeutics. Hitherto, this approach has resulted in a joint patent application and several manuscripts that have either been published or are under preparation. Most attention to date has gone to investigation of UAMC-2526, an Atg4B-targeting autophagy inhibitor that ...

Prospective Sustainability Assessment of Emerging Biopharmaceutical Manufacturing Technologies; An integrated Approach towards Considering Environmental and Economic Life Cycle Impacts Ghent University

Jo Dewulf
Department of Green Chemistry and Technology, Department of Sustainable Organic Chemistry and Technology

The project aims at assessing the sustainability of emerging biopharmaceutical production processes considering both environmental and economic aspects by combining Life Cycle Assessment and Life Cycle Costing. New methods will be developed to estimate the required data to forecast the environmental and economic sustainability of these technologies at pilot and at full scale.

Development and integrated use of novel preclinical models to assess intestinal absorption and hepatic elimination in order to achieve accelerated biopharmaceutical drug profiling. KU Leuven

Patrick Augustijns
Drug Delivery and Disposition
The multitude of processes involved in oral drug disposition along with the complexity of their interplay is typically not covered in the current array of assays applied during biopharmaceutical drug profiling. A major consequence is that insufficient insight is gained into the specific mechanisms playing key roles in drug disposition of a given drug candidate. The present research proposal pursues to develop novel preclinical tools to better ...