Projects
Development of a biomimetic cornea combining additive manufacturing and stem cell technologies. University of Antwerp
Development of biomimetic responsive nanocarriers for inhalable drug delivery in lung cancer Hasselt University
Generation of purified biomimetic nanoparticles to stimulate therapeutic delivery to tumor cells KU Leuven
To date, nanoparticle delivery to solid tumors in general, and the specific delivery to cancer cells has remained very low, as most nanoparticles are rapidly sequestered from the blood. To overcome this problem, scientists have looked at the concept of biomimetics, where engineered nanomaterials are surrounded by membranes isolated from natural cells in order to trick the immune system and delay nanoparticle clearance. Here, we aim to improve ...
Green and Sustainable Synthesis of Mesoporous Metal-Organic Frameworks to Bring New Life to Hydrogen-Bond Donating (HBD) Organocatalysts as Biomimetic Platforms. University of Antwerp
3D Biomimetic model of the host-microbiome small intestinal ecosystem Ghent University
The human gut forms a complex ecosystem where the intestinal barrier faces the resident
microbiota. This microbiota is involved in maintaining gut homeostasis, occupying luminal and
mucosal niches to outcompete pathogenic bacteria, providing a protective biofilm, contributing to
the digestion of foods and energy metabolism, and also actively modulating immune processes.
Microbe-host crosstalk is hence considered a ...
3D Biomimetic model of the host-microbiome small intestinal ecosystem KU Leuven
The human gut forms a complex ecosystem where the intestinal barrier faces the resident microbiota. This microbiota is involved in maintaining gut homeostasis, occupying luminal and mucosal niches to outcompete pathogenic bacteria, providing a protective biofilm, contributing to the digestion of foods and energy metabolism, and also actively modulating immune processes. Microbe-host crosstalk is hence considered a crucial determinant of human ...
Microscopy toolbox for structural and thermo-mechanical characterisation of new biomimetic materials KU Leuven
Organ failure and tissue lost are challenging health issues due to the lack of organs for transplantation and the limitations of conventional artificial implants. Tissue engineering has emerged as a promising approach to generate biological substitutes. In tissue engineering applications, cells are grown in a three-dimensional platform which is known as a scaffold. In the last years a great effort has been made in the development of new ...
Linking properties of biomimetic polymer matrices to stem cell fate: a microscopy study KU Leuven
Living tissues are more than packed cells. In fact, much of a tissue's volume is made up of extracellular space, filled with a complex meshwork of sugars, water, minerals and proteins called the extracellular matrix (ECM). Besides providing a structure support to the cells, the ECM plays a crucial role in several cellular processes, such as cell survival, development, adhesion and differentiation of stem cells. When a stem cell divide, it ...
The development of a biomimetic cell-based construct for osteochondral regeneration using 3D bioprinting technology. KU Leuven
The edges of long bones that meet in a joint are covered with articular cartilage, a highly specialized tissue that protects the epiphyses from the friction and compression forces exerted in a joint. The joint surface cartilage can be damaged due to injury, disease or chronic conditions. Unfortunately, the articular cartilage has limited healing potential and defects in the articular surface can progress into the underlying subchondral bone. ...