Projects
Validation of autophagy induction as a therapeutic strategy: from drug discovery and preclinical evaluation to safety investigation and biomarker research. University of Antwerp
Development and strategic basic research towards an innovative biomarker for productive longevity in high-yielding dairy cattle. Ghent University
The steep increase in individual milk yield of modern dairy cows has unfortunately been accompanied by a decrease in cows’ lifespan. Nonetheless, greater productive longevity can improve the profitability of a dairy herd by lower culling rates and a lower need for replacement heifers, a higher overall milk production, an improved public opinion about dairy cow welfare and a decrease of the environmental footprint of dairy herds. The major gap ...
ADMIRE: Association, causality and biomarker Discovery in translational MIcrobiome REsearch. Hasselt University
Molecular genetics and biomarker research of frontotemporal lobar degeneration supported by robust biosampling and biobanking strategies. University of Antwerp
Research into biomarkers for early detection of Autosomal Dominant Polycystic Kidney Disease KU Leuven
The kidneys, two bean shaped organs located on either side of the spine in the back of the abdomen, are important excretory organs of the human body. Apart from the removal of waste, kidneys have other important functions such as maintaining the blood pressure and the activation of vitamin D. Since these tasks are essential for a healthy life, we can say that a good renal function is vital. Nevertheless, today exist a variety of kidney ...
Role of innovative research tools as biomarkers to predict severe clinical complications in Systemic Sclerosis. Ghent University
Systemic sclerosis (SSc) is a rare connective tissue disease which is characterised by serious morbidity and mortality. As nowadays certain disease modifying therapies are at hand it may be opportune to identify biomarkers which predict these clinical complications. This research proposal has the aim to investigate the predictive performance of three innovative research tools: nailfold videocapillaroscopy, laser and SSc-specific ...
Nephrogenesis in extremely low birthweight infants and nephropathogenesis in relation to biomarkers and research to long distance prognosis KU Leuven
The aims of this PhD–project were to a) determine screening criteria for HNF1B analysis in patients with congenital anomalies of kidney and urinary tract (CAKUT), b) generate an infrastructure to facilitate longitudinal follow–up of a birth cohort of former extremely low birth weight (ELBW) neonates and subsequent data pooling with other cohorts and c) to use this infrastructure to study the consequences of preterm birth and ...
Cardiovascular dysfunction after cancer radiation therapy: search for biomarkers and study of the underlying physiological mechanisms. University of Antwerp
The search for biomarkers in systemic treatment of advanced hepatocellular carcinoma. KU Leuven
The combination of immune checkpoint inhibitors with anti-angiogenic agents has revolutionized the treatment landscape of advanced hepatocellular carcinoma (HCC). As more therapies become available, each effective in a, yet undefined, subgroup of patients, managing advanced HCC well has become increasingly complex. With the fast pace at which the landscape evolves and the lack of data on head to head comparisons of novel regimens, an ...