Angiogenic-osteogenic coupling: the role of the PDGF family in the crosstalk between osteoprogenitors and endothelial cells, and implications thereof in bone biology and repair KU Leuven
Osteoporosis-induced fractures pose an increasing medical and economic burden. There is a large interest in osteo-anabolic therapies that can restore the low bone mass in osteoporotic patients to reduce the fracture risk, or stimulate bone formation when healing is compromised. It is well known that the presence of blood vessels is absolutely required for bone formation, but our understanding of this coupling is incomplete. Intriguingly, ...