Publications
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Kindia (Pavetteae, Rubiaceae), a new cliff-dwelling genus with chemically profiled colleter exudate from Mt Gangan, Republic of Guinea Ghent University
Evolutionary trends in the columnar cactus genus Eulychnia (Cactaceae) based on molecular phylogenetics, morphology, distribution, and habitat Ghent University
Adverse outcome pathways: opportunities, limitations and open questions Vrije Universiteit Brussel
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event relationships (KER). Although this approach to formalize mechanistic toxicological information only started in ...
Opportunities and challenges of molecular epidemiology Vrije Universiteit Brussel
Recursive DNA assembly using protected oligonucleotide duplex assisted cloning (PODAC) Ghent University
From Bench to Bedside Vrije Universiteit Brussel
Although sequencing technology has become widely available in recent years, the steps in bioinformatics pipelines are time-consuming and barely standardized. New tools to improve individual steps in a pipeline are frequently published and configurations can be quickly adapted to use new versions. We performed case studies with a representative set of pipeline management tools using the GEP-R pipeline, and a qualitative study of different ...
Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange Ghent University
Gene engineering in mouse embryos or embryonic stem cells (mESCs) allows for the study of the function of a given protein. Proteins are the workhorses of the cell and often consist of multiple functional domains, which can be influenced by posttranslational modifications. The depletion of the entire protein in conditional or constitutive knock-out (KO) mice does not take into account this functional diversity and regulation. An mESC line and a ...