Projects
Conceptual Density Functional Theory :alternative computational techniques for reactivity descriptors and applications on molecules, solid state and biological systems Vrije Universiteit Brussel
Genomic and transcriptoomproflering neuroblastoma: identification of prognostic diagnostic expression signatures, unraveling the MYCN transcriptional network and study of the biological role v chromosome 17q gain.. Ghent University
Anlaysis of the genetic defect in melorheostosis and the study of the molecular and biological effects of LEMD3 haploinsufficiency Ghent University
In 2004, we demonstrated that loss-of-function mutations in LEMD3 can lead to osteopoikilosis, the Buschke-Ollendorff syndrome (BOS) and non-sporadic melorheostosis. This project aims 1) to identify the causal genetic defect in sporadic melorheostosis though a candidate gene approach, and 2) to study the biological effects of LEMD3 haploinsufficiency and the pathways that lead to the hyperostotic lesions in these skeletal dysplasias.
Molecular and cell biological analysis of the role of the PDZ proteins in in tumorgeassocierde processes. Ghent University
Fluorinations with implications: enhancing the potential of biologically and medicinally interesting molecules through targeted fluorine introduction Ghent University
The process of developing bioactive compounds into drugs is notoriously difficult, costing the pharmaceutical industry years and billions of dollars per drug. The motivation of our research programme is to develop methodologies to improve and accelerate such efforts. The application encompasses three projects, all focused on improving physical properties of bioactive compounds. It is indeed only a recent but very firm realisation that ...
Employment of functionalized azetin-2-ones for the synthesis of biologically relevant C-, N- and spiro-fused beta-lactams. Ghent University
The study of beta-lactams has become a topic of considerable interest in many disciplines, especially in terms of their synthetic elaborations and biological applications. The project in hand has the ambition to contribute to this field through the generation of new fundamental insights into the chemistry of beta-lactams and the application of this knowledge to construct biologically relevant new beta-lactam compounds.
Controlling biologically inspired robots using morphological computatrion Ghent University
This research will focus on the locomotion of robots by studying morphological computation. Morphological computation, a new domain in the field of biologically inspired robotics, investigates the relationship between body, brain and environment.
The goals are: to study morphological computation theoretically, to develop design principles for biologically inspired robots, and to evaluate these principles in simulation and by ...
Rational design of biologics for therapeutic development (FoldCo) Ghent University
Thirty-six antibody-based biologics achieved blockbuster drug status (yearly sales exceeding a billion dollars) last year, and Humira alone generated $19.9 billion of global sales. Most biologics are monoclonal antibodies that, due to their extreme specificity, hold the promise to treat a variety of medical conditions for which no other treatments are currently available. Biologic drug development, however, still suffers from a high attrition ...