Projects
A statistical bioinformatics workflow to fuel proteomics-driven precision medicine. Hasselt University
Antwerp core facility for bioinformatics (BIOMINA). University of Antwerp
Improved data-driven bioinformatics tools to greatly extend neo- and xeno-epitope landscapes detected by immunopeptidomics. Ghent University
Vaccination has proven to be very successful, resulting in the eradication of smallpox and the near-eradication of poliovirus, for example. Currently, vaccination is available for over 29 diseases and is estimated to prevent over 3 million deaths a year. However, for some diseases such as cancer and tuberculosis, effective vaccines are not yet available. A major problem in developing vaccines for diseases such as cancer and those caused by ...
Bioinformatics for single-cell sequence and in situ RNA analytics to study cell niches and cell-cell interaction KU Leuven
single-cell RNA-seq procedures alone are insufficient to deliver comprehensive insight in organ cell atlases in health and disease. Indeed, as most of our organ functions are executed by the concerted action of individual cells in a spatially organized context, it is paramount to research single cells in their native spatial context. This is not only important to understand normal organ development and function, but also to investigate how ...
Marine biodiversity multi-omics: Bioinformatics pipeline and long-read sequencing optimization KU Leuven
Marine biodiversity is huge and the latest findings reveal a new world of so far unexpected functions and dynamics. Moreover, biodiversity plays a critical role in the understanding of global change (especially the overexploitation of living resources, habitat loss and climate change). Technological developments such as autonomous field deployed robots and high-throughput sequencing have contributed significantly to advances in marine ...
Applying bioinformatics in dendritic cell-mediated immune cell activation research: automated analysis of high-dimensional flow cytometry datasets. University of Antwerp
Identification of pan-cancer and tumor-specific methylation based biomarkers and development of bioinformatics infrastructure for a novel multiplex methylation assay. University of Antwerp
PhD position in Bioinformatics and Genomics KU Leuven
De nieuwe generatie sequencing technoligieën zijn deel geworden van het klinisch diagnostisch process. Recentelijk werd ook volledige genoom analyse (WGS) toegankelijk voor de routine diagnostiek en zijn we deze methodiek aan het implementeren. Een eerste doelstelling van deze Ph.D thesis is om WGS analyse te implementeren, te standardiseren en de beschikbare algorithmen verder te optimaliseren voor variatie analyse en de kwaliteitsparameters ...
Bioinformatics for a high-throughput deep mutational scanning protein-protein interaction assay: turning a prototype into a precision medicine toolbox Ghent University
This proposal contributes to the development of a high-throughput method to characterize the impact of nearly every mutation on specific protein-protein interactions. After bioinformatics-driven experimental optimization, this method will be applied to tumor-driver protein interactions (TP53, PTEN, PIK3R1) and results compared to large-scale tumor mutation and gene expression data. This will allow to demonstrate the major relevance for ...