Publications
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Strategies to reduce aspecific adsorption of peptides and proteins in liquid chromatography-mass spectrometry based bioanalyses: An overview Vrije Universiteit Brussel
In the drug-discovery setting, the development of new peptide and protein-based biopharmaceuticals attracts increased attention from the pharmaceutical industry and consequently demands the development of high-throughput LC-MS methods. Regulatory guidelines require bioanalytical methods to be validated not only in terms of linearity, sensitivity, accuracy, precision, selectivity and stability, but also in terms of carryover. Carryover results ...
Clinical application of microsampling versus conventional sampling techniques in the quantitative bioanalysis of antibiotics : a systematic review Ghent University
Bioanalysis for Biosimilars Development KU Leuven
According to PubMed, the term ‘biosimilar’ has existed for 10 years in scientific literature, with the first biosimilar having been introduced onto the European market in 2006. Early biosimilars concerned relatively small proteins such as human growth hormone, epoetin and filgrastim. In 2013, the first biosimilar monoclonal antibody (infliximab) was approved. It is beyond any doubt that the emergence of biosimilars has an important impact on ...
Insights resulting from quantitative bioanalysis in studies of drugs and driving Ghent University
In this study we examined the value of quantitative bioanalysis of drugs in studies on drugs and driving. Based on the fact that the use of psychoactive substances should not be combined with driving, one could argue that, especially for routine testing for driving under influence of drugs, reporting quantitative results is not necessary and that it is sufficient to determine the presence or absence of a drug (class) to study the prevalence of ...
Optimization of bioanalysis of dried blood samples University of Antwerp
Introduction: Pharmacokinetic/pharmacodynamic modelling has emerged as a valuable technique for understanding drug exposure and response relationships in drug development. Pharmacokinetic data are often obtained by taking multiple blood samples, which may disturb physiological parameters and complicate study designs. Wearable automatic blood sampling systems can improve this limitation by collecting dried blood samples at programmable time ...
Fit-for-Purpose Quality Control System in Continuous Bioanalysis during Long-Term Pediatric Studies (vol 21, 104, 2019) KU Leuven
The LENA collaborator list below was not included in the original article.s.