Publications

The spin scattering induced by magnetic adsorbates on graphene was studied using a combination of transport measurements on a graphene field effect transistor decorated with atomically precise nickel clusters and first principles calculations. A comparative study before and after deposition of Ni4 clusters unambiguously corroborated the contribution of the added scatterers. An investigation of the spin scattering parameters as a function of the ...

SnSe2 with high theoretical capacity has been identified as an emerging anode candidate for lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs). However, the rate performance and cycling performance of this material in practical applications are still limited by unavoidable volume expansion and low conductivity. In this work, we designed and synthesized nitrogen-doped carbon-coated SnSe2/C-N composites using 2-aminoterephthalic acid ...

Recent efforts in the study of vector-borne parasitic diseases (VBPDs) have emphasized an increased consideration for preventing drug resistance and promoting the environmental safety of drugs, from the beginning of the drug discovery pipeline. The intensive use of the few available antileishmanial drugs has led to the spreading of hyper-resistant Leishmania infantum strains, resulting in a chronic burden of the disease. In the present work, we ...

NIPP1, for Nuclear Inhibitor of Protein Phosphatase 1 (PP1), belongs to the large group of regulatory interactors of PP1, known as RIPPOs. NIPP1 associates with approximately one-third of the nuclear pool of PP1, forming the nuclear phosphatase holoenzyme PP1:NIPP1. The N-terminal ForkHead-Associated (FHA) domain of NIPP1 is a protein module that specifically binds to a phosphate group of proteins with a phosphorylated threonine followed by a ...

Serum-derived bovine immunoglobulin (SBI) prevents translocation and inflammation via direct binding of microbial components. Recently, SBI also displayed potential benefits through gut microbiome modulation. To confirm and expand upon these preliminary findings, SBI digestion and colonic fermentation were investigated using the clinically predictive ex vivo SIFR® technology (for 24 human adults) that was, for the first time, combined with host ...

Cell fate is tightly controlled by a continuous balance between cell survival and cell death inducing mechanisms. B-cell lymphoma 2 (Bcl-2)-family members, composed of effectors and regulators, not only control apoptosis at the level of the mitochondria but also by impacting the intracellular Ca2+ homeostasis and dynamics. On the one hand, anti-apoptotic protein Bcl-2, prevents mitochondrial outer membrane permeabilization (MOMP) by scaffolding ...

An increasing body of evidence indicates that oncogenic signalling enhances protein synthesis in both the cytosol and mitochondria and that this increase is essential to cancer cell survival. Targeting translational rewiring may therefore offer novel therapeutic opportunities. However, given its essential role in normal cells, modulating translation in a cancer-cell specific manner remains a major challenge. LncRNA (Long non-coding RNA) ...

OBJECTIVES: Guanine nucleotide-binding protein alpha-activating activity polypeptide O (GNAO1) syndrome, a rare congenital monogenetic disorder, is characterized by a neurodevelopmental syndrome and the presence of dystonia. Dystonia can be very pronounced and even lead to a life-threatening status dystonicus. In a small number of pharmaco-refractory cases, deep brain stimulation (DBS) has been attempted to reduce dystonia. In this study, we ...

INTRODUCTION: Although checkpoint inhibitors (CPIs) have improved outcomes for patients with metastatic melanoma, those progressing on CPIs have limited therapeutic options. To address this unmet need and overcome CPI resistance mechanisms, novel immunotherapies, such as T-cell engaging agents, are being developed. The use of these agents has sometimes been limited by the immune response mounted against them in the form of anti-drug antibodies ...

Bacteriophages must seize control of the host gene expression machinery to replicate. To bypass bacterial anti-phage defence systems, this host takeover occurs immediately upon infection. A general understanding of phage mechanisms for immediate targeting of host transcription and translation processes is lacking. Here we introduce an integrative high-throughput approach to uncover phage-encoded proteins that target the gene expression machinery ...