Transcriptional bet hedging as a resilience strategy in the human gut microbiome (Gut-BET) KU Leuven
The gut microbiota is essential for intestinal homeostasis, yet how it keeps its resilience from external perturbations is unclear. Previous work has shown that various drugs can lead to dysbiosis in patients with gastrointestinal pathologies, but the mechanisms by which the microbiota recovers from these insults is not understood. Here, we hypothesise that the microbiota uses so-called ‘bet hedging’ approaches to this aim, in which a subset ...