Exploiting lncRNAs to drug the undruggable in BRAF wild-type melanoma. KU Leuven
Targeting translation has a strong therapeutic potential, however, modulating translation in a cancer-cell specific manner remains challenging. Increasing evidences support the idea that translational rewiring is essential for growth, progression and development of drug resistance in melanoma.
LncRNAs are RNAs not-coding for proteins and longer than 200 nucleotides that exhibit cancer-specific expression and can be targeted efficiently ...