BNIP3 AND ITS ROLE IN MODULATING THE INTERFACE BETWEEN MELANOMA CELLS AND IMMUNE CELLS KU Leuven
The hypoxia responsive protein BNIP3 plays an important role in promoting cell death and/or autophagy, ultimately resulting in a cancer type-dependent, tumour-enhancer or tumour-suppressor activity. We previously reported that in melanoma cells, BNIP3 regulates cellular morphology, mitochondrial clearance, cellular viability and maintains protein expression of CD47, a pro-cancerous, immunosuppressive 'don't eat me' signal. Surface-exposed ...