Structure-guided design of BK/JC virus capsid targeting antivirals KU Leuven
BK and JC viruses are closely related members of the polyomavirus family that latently infect 70-90% of humans and cause fatal clinical complications in immunocompromised patients (kidney failure and brain demyelination). There are no effective drugs to treat these infections. The lack of conventional, enzymatic antiviral targets such as proteases or integrases makes any development challeging. The small genome of polyomaviruses encodes two ...