Using BRET-based G protein biosensors to unravel the G protein mediated pathways in insects KU Leuven
G protein-coupled receptors (GPCRs) are membrane-bound receptors which are candidate targets for novel insect pest management strategies. The superfamily of GPCRs is extensively studied in vertebrates since they are pharmacological targets for many important therapeutic compounds. However, in insects, the molecular signaling properties of GPCRs remain poorly understood and studies are usually limited to the detection of fluctuations in the ...