Projects
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Research to establish specific product and process characteristics from an innovative technological process to produce inserts loaded with peptides/proteins. University of Antwerp
In the research group Pharmaceutical Technology and Biopharmacy a new method of preparation for ocular dosage forms loaded with peptides and/or proteins has been developed. In this proof-of-concept study, product characteristics and process parameters from the invention will be optimized. The physico-chemical characteristics of the intermediate product and final product from the innovative technological process are evaluated together with ...
Development, evaluation and optimization of ocular drug delivery concepts for the use in dry eye syndrome and retinal disorders. University of Antwerp
Several ocular drug delivery concepts will be developed, characterized in vitro and ex vivo and evaluated in vivo. First the peptide cyclosporine is selected for the development of the concepts. Afterwards, the most promising formulation will be further developed for retinal disorders with a specific peptide.
Research in formulation of poorly watersoluble active compounds in PLGA Nanoparticles using spray-drying technology. University of Antwerp
The poor water-solubility of new active pharmaceutical ingredients (API) is a true challenge for formulation experts. Before an API can reach the systemic circulation and reach the target site of action, orally-taken drugs need to dissolve first in the gastrointestinal fluids. The use of organic solvents in high-throughput screening of new API's, as well as the structure-activity related research, often results in candidate-molecules with an ...
Research in Formulation and Processing of Probiotics in Buccal Dosage Forms. University of Antwerp
Environmental Ecology & Applied Microbiology (ENdEMIC), Laboratory of Pharmaceutical Technology and Biopharmacy
In case of many nasopharyngeal diseases, such as otitis media, acute and chronic sinusitis and pharyngitis, patients frequently resort to self-medication using over-the-counter products. Often, clinical data is lacking to support the use of decongestive, expectorantia or nasal salt solutions and relapse is frequent. On the other hand, (ab)use of antibiotics is linked with the resistance-issue. Main idea of this project is that local buccal or ...
Versatile X-ray powder diffraction platform for materials science. University of Antwerp
Laboratory of Pharmaceutical Technology and Biopharmacy, Laboratory of adsorption and catalysis (LADCA), Intelligence in PRocesses, Advanced Catalysts and Solvents (iPRACS)
The proposal concerns versatile instrumentation for determining crystallinity, unit cell size and structure of organic, metal-organic and inorganic materials. Several groups at UAntwerp have a pressing need for fast, reliable, X-ray diffraction data, at low angles to determine large unit cells, and preferably in 2D to determine sample homogeneity. The envisaged machine has a Cu K alpha source, horizontal sample platform (Bragg-Brentano ...
Drug delivery systems and in vivo efficacy of the serine protease inhibitor UAMC-00050 in a preclinical model for irritable bowel syndrome. University of Antwerp
Laboratory of Pharmaceutical Technology and Biopharmacy, Medicinal Chemistry (UAMC), Laboratory Experimental Medicine and Pediatrics (LEMP)
The serine protease inhibitor UAMC-00050, previously shown efficacious in 2 preclinical IBS models after systemic administration, will be formulated for oral and rectal administration. The drug delivery systems will be tested in the rat IBS model for dose determination, efficacy, time of administration and serum concentrations, a crucial step towards further valorization of the compound.
In vivo POC of potential respiratory probiotic strains (REINSPIRE). University of Antwerp
Translational Neurosciences (TNW), Laboratory of Pharmaceutical Technology and Biopharmacy, Primary and interdisciplinary care Antwerp (ELIZA), Environmental Ecology & Applied Microbiology (ENdEMIC)
Probiotics are defined as live microorganisms which, when applied inadequate amounts, confer a health benefit to the host (FAO/WHO, 2001). These microbes are generally applied in the gastrointestinal tract via fermented food products or capsules. In previous research, we isolated bacterial strains with potential probiotic properties for the upper respiratory tract based on in vitro laboratory tests and genome sequencing. Here, we want to deliver ...
Medicinal Chemistry-Drug Discovery (ADDN). University of Antwerp
Laboratory of Pharmaceutical Technology and Biopharmacy, Medical Biochemistry, Natural Products and Food - Research and Analysis (NatuRA), Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Pathophysiology, Translational Pathophysiological Research (TPR), Medicinal Chemistry (UAMC)
This project represents a research contract awarded by the University of Antwerp. The supervisor provides the Antwerp University research mentioned in the title of the project under the conditions stipulated by the university.
The influence of probiotic watercontent and wateractivity in spray-dried nasopharyngeal and buccal formulations. University of Antwerp
This project investigates how the critical formulation and process parameters influence the zeta-potential and the wateractivity in nasal/buccal sprays and lozenges of spray-dried probiotics, in particular with Lactobacillus rhamnosus species. The link between wateractivity, absolute water content and cell viability will be investigated immediately after production and in a stability study.