Projects
BetaCellTherapy : Beta Cell Therapy in Diabetes. Vrije Universiteit Brussel
Interactome analysis between Pseudomonas aeruginosa and its bacteriophages: elucidation of the phage infection mechanism and identification of novel antibacterial targets. KU Leuven
Comparative biochemical and functional study of the different dipeptidyl peptidases. University of Antwerp
De novo sequence analysis and C-terminal sequence analysis via high throughput proteomics using robotics and MALDI-TOF/TOF MS Ghent University
The goal of this project is the automatisation of a set of chemical and cleavage and derivatisation methods for proteins, developed at the laboratory for protein biochemistry and protein engineering. These methods allow a better characterisation of proteins in proteomic projects using MALDI TOF/TOF MS analysis. Applications cover an improved characterization of C-terminal processing of human proteins. Automatization will allow to dramatically ...
Lipid-containing extracellular vesicles as mediators of remyelination and biomarkers in mutliple sclerosis Hasselt University
Improved methods for spatial-temporal fluorescence imaging of cell activity KU Leuven
The PhD projects aim to develop a new methodology to extract superresolution spatial-temporal information on cell activity in response to some external stress. This will provide new insights into how biological systems are structured at the nanoscale, and how this structures provides e.g. signaling specificity, using the latest methodologies in imaging and data analysis.
Maternale obesitas en "fetal programming": de gevolgen voor de voortplantingsfysiologie van de nakomelingen. University of Antwerp
Faster imaging with reduced toxicity through compressed sensing and data learning KU Leuven
Confocal-based and wide-field fluorescence microscopy are widely used techniques to investigate inter- and intracellular phenomena in live-cells and organoid systems. In these high-dimensional systems, the temporal and spatial resolution are limited by phototoxicity and imaging speed and there are no ways to efficiently deal with this. The aim of the project is to enhance imaging performance (faster, less light exposure), while retaining the ...
Development of genetically encoded biosensors for super-resolution optical fluctuation imaging KU Leuven
Life is dynamic, defined by the ability to maintain homeostasis in ever-changing environments. On a cellular level, this requires an intricate regulatory network to manage activities and reactivities in response to external stimuli. Fluorescence microscopy provides us a window into this dynamic realm of subcellular signalling. The complex spatiotemporal regulation of this network can be investigated with fluorescent indicators, remarkable ...