Projects
Investigation of molecular mechanisms of trehalose-6-P in lateral root development and on stomatal aperture. KU Leuven
Trehalose metabolism in plants is becoming a hot topic, because it affects a lot of agricultural important characteristics such as growth, stress tolerance and sugar partitioning. For instance, the intermediate molecule during its biosynthesis, trehalose-6-phosphate (T6-P) connects the sugar status with plant growth and development. However, the underlying working mechanism is not clear. The trehalose-6-phosphate phosphatase (TPP) gene family ...
ZAP office in Cardiology Small Pets Ghent University
LncRNAs as modulators of protein synthesis rewiring in cancer KU Leuven
An increasing body of evidence indicates that MYC and RAS-induced oncogenic signalling enhances protein synthesis in both the cytosol and mitochondria and that this increase is essential to cancer cell survival. Targeting translational rewiring may therefore offer novel therapeutic opportunities. However, given its essential role in normal cells, modulating translation in a cancer-cell specific manner remains a major challenge. LncRNA (Long ...
Development of photo-activatable protease inhibitors and activity-based probes and their application in the study of dynamic proteolytic processes KU Leuven
Proteases are involved in many highly regulated biological processes, such as apoptosis, cell-cell communication and blood coagulation. Inhibitors and activity-based probes (ABPs) have been successfully utilized as chemical tools to study these enzymes. However, when studying fast and dynamic processes, local and temporal acivation of these reagents is desirable. Such reagents can first of all be used for basic study of these processes, but ...
The molecular basis of the growth promoting capacity of a Caulobacter sp. on Arabidopsis thaliana Ghent University
A Caulobacter sp., originating from maize roots, exerts a plant growth promoting effect on both maize and Arabidopsis thaliana. Until now our knowledge on the molecular basis of this plant-microbe interaction is very scarce. Via transcriptomics, proteomics and phosphoproteomics we aim at gaining molecular insights into the processes that give rise to the observed growth promoting phenotype.
A Song of Bone and Fire – A Clash of Worlds Vrije Universiteit Brussel
Cr(VI)-free pre-treatments for adhesive bonding of aerospace Al alloys Vrije Universiteit Brussel
The coastal ocean: hotspot of global change. University of Antwerp
γ-Secretase structure-function studies by means of Nanobodies KU Leuven
Synopsis: γ‑Secretases (GSECs) are intramembrane cleaving proteases (I‑CLiPs) involved in essential physiological signalling cascades, and disease processes. GSECs consist of four essential subunits, namely nicastrin (NCSTN), anterior pharynx defective 1 (APH1), presenilin enhancer 2 (PEN‑2), and its catalytic subunit presenilin (PSEN). Typically, substrates of GSECs are type I single‑pass transmembrane proteins, such as the amyloid precursor ...