Structural, functional and regulatory plasticity of giant metabolic enzymes (LIPOFLUXCONTROL) Ghent University
Organisms across all kingdoms of life crucially rely on the high-energy metabolite acetyl-CoA in the cellular cytosol to fuel
pivotal biochemical processes such as fatty acid and cholesterol synthesis, and protein acetylation. However, the metabolic
availability of acetyl-CoA is by no means a sinecure. Acting as a metabolic hub, ATP citrate lyase (ACL) harnesses the
hydrolysis of ATP and metabolically generated citrate and ...