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Biocatalysis toward new biobased building blocks for polymeric materials KU Leuven
© 2016 Wiley-VCH Verlag GmbH & Co. KGaA. This chapter describes the role of biocatalysis in the context of these paradigm shifts: not only in a classical way via exemplary biocatalysis cases and criteria for new biobased building blocks (newBBBBs), and not only as an isolated scientific competence used for producing a defined set of chemicals for modern plastics, but also reflecting on the industrial framework and underlying principles ...
Study on the Properties of Immobilized Biocatalysts with Lipase Activity Produced by Yarrowia lipolytica in Batch Culture KU Leuven
Three kinds of matrices (calcium alginate, gelatin, and PVA) were employed as supports to immobilize lipases from Y. lipolytica KKP 379 via physical adsorption. The stability of biocatalysts (free and immobilized) was evaluated by measuring the enzyme activity before and after treatment with the method based on the hydrolysis of p-nitrophenyl laurate. Two fractions of enzymes were immobilized: Cell-bound (yeast biomass) and extracellular ...
Polydopamine nanocoated whole-cell asymmetric biocatalysts University of Antwerp
Our whole-cell biocatalyst with a polydopamine nanocoating shows high catalytic activity (5 times better productivity than the native cell) and reusability (84% of the initial yield after 5 batches, 8 times higher than the native cell) in asymmetric reduction. It also integrates with titania, silica, and magnetic nanoparticles for multi-functionalization.
Understanding the molecular basis of industrially relevant biocatalysts University of Antwerp
Chlorite dismutases (Clds) are heme b-containing oxidoreductases of bacterial origin which degrade chlorite to form chloride and molecular oxygen. This unique enzymatic activity was originally found in perchlorate- and chlorate-reducing bacteria, where Clds act as scavenging systems for the toxic chlorite produced during the respiration. In addition to their intriguing reactivity – the formation of an O-O bond was formerly described only for ...
Biocatalysts for multicomponent Biginelli reaction: bovine serum albumin triggered waste-free synthesis of 3,4-dihydropyrimidin-2-(1H)-ones KU Leuven
Bovine serum albumin (BSA) promoted simple and efficient one-pot procedure was developed for the direct synthesis of 3,4-dihydropyrimidin-2(1H)-ones including potent mitotic kinesin Eg5 inhibitor monastrol under mild reaction conditions. The catalyst recyclability and gram scale synthesis have also been demonstrated to enhance the practical utility of process.