Projects
Evolution in practice: converting hydrolases and transferases into phosphorylases Ghent University
Carbohydrates and derivatives hold great potential for numerous industrial applications. Yet, they are not being fully exploited due to the scarce nature of many of these compounds. Carbohydrate-active enzymes and especially glycoside phosphorylases (GPs) are promising biocatalysts for the production of these so-called rare sugars. Unfortunately, only a small set of phosphorylases has been discovered to date. This PhD project will address ...
Microbial cell factories to convert food waste into high-value chemicals KU Leuven
From early days, microbial processes have been exploited for the production of food and commodity products. The advent of genetic engineering and biotechnology has allowed the rational design of cell factories that produce biobased products from renewable feedstock. However, current approaches are often laborious and time-consuming. Recent advances in synthetic biology allow the design and construction of artificial metabolic pathways. This ...
Retracing the steps of enzyme evolution: an exploration of ancestral sequence space Ghent University
Enzymes can be used to catalyse reactions with splendid control over specificity and selectivity. However, their high degree of specialisation sometimes narrows down their application potential or complicates their engineering towards different functions. There are indications that ancestral enzymes used to be more promiscuous and more mutationally flexible, and therefore, they may hold great biotechnological appeal. Sadly, not much is ...
GlycoProFit: Cost-efficient synthesis of health-promoting glycobioses Ghent University
The project aims to establish the Cost-efficient synthesis of health-promoting glycobioses using classical table sugar (sucrose) as substrate and enzymes as green biocatalysts. After synthesis of various new disaccharides (analogues), they will be studied in detail to determine their characteristics in food applications. The most promising candidates will then be produced at large-scale to enable their taste and texture profiling.
GlycoProFit: Cost-efficient synthesis of health-promoting glycobioses Ghent University
The project aims to establish the Cost-efficient synthesis of health-promoting glycobioses using classical table sugar (sucrose) as substrate and enzymes as green biocatalysts. After synthesis of various new disaccharides (analogues), they will be studied in detail to determine their characteristics in food applications. The most promising candidates will then be produced at large-scale to enable their taste and texture profiling.
GlycoProFit: Cost-efficient synthesis of health-promoting glycobioses Ghent University
The project aims to establish the Cost-efficient synthesis of health-promoting glycobioses using classical table sugar (sucrose) as substrate and enzymes as green biocatalysts. After synthesis of various new disaccharides (analogues), they will be studied in detail to determine their characteristics in food applications. The most promising candidates will then be produced at large-scale to enable their taste and texture profiling.
GlycoProFit: Cost-efficient synthesis of health-promoting glycobioses Ghent University
The project aims to establish the Cost-efficient synthesis of health-promoting glycobioses using classical table sugar (sucrose) as substrate and enzymes as green biocatalysts. After synthesis of various new disaccharides (analogues), they will be studied in detail to determine their characteristics in food applications. The most promising candidates will then be produced at large-scale to enable their taste and texture profiling.
GlycoProFit: Cost-efficient synthesis of health-promoting glycobioses Ghent University
The project aims to establish the Cost-efficient synthesis of health-promoting glycobioses using classical table sugar (sucrose) as substrate and enzymes as green biocatalysts. After synthesis of various new disaccharides (analogues), they will be studied in detail to determine their characteristics in food applications. The most promising candidates will then be produced at large-scale to enable their taste and texture profiling.
Spatial control of enzymatic DNA assembly using ion charging layers KU Leuven
In recent years, significant progress has been made in the development of microchip-based gene synthesis technologies, particularly in the area of enzymatic DNA synthesis. While traditional DNA synthesis methods rely on the phosphoramidite chemistry, this approach has several limitations. For example, it requires excessive solvent use, is expensive, and is not readily amenable to miniaturization. In contrast, enzymatic DNA synthesis, which ...