Projects

Increasing lines of evidence indicate that mast cells (MC) degranulation from off-target occupation of the Mas-related G protein coupled receptor X2 (MRGPRX2) constitutes a novel endotype of IgE/FcεRI (high affinity receptor for IgE) -independent drug anaphylaxis. However, most of the data have been gathered in mice or in malignant mast cell lines. In contrast to MC, MRPGPRX2 is barely expressed on basophils membrane but quickly upregulated ...

Allergy during anaesthesia is an important health problem with a significant mortality and morbidity. Unfortunately, correct diagnosis is not always straightforward and too frequently overlooked. As a consequence, patients are at unnecessary risk for future life-threatening reactions. Uncertainties associated with skin testing using some of these drugs and the general unavailability of drug-specific immunoglobulin E tests contribute to the ...

Nonspecific-lipid transfer proteins (ns-LTPs) have increasingly been recognized to constitute a significant cause of plant food allergy. Sensitization to ns-LTPs was predominantly observed in adults and appeared mainly associated with severe generalized reactions. However, we established that in northern Europe sensitization to ns-LTP can also occur in children and that the sensitization profile assessed by quantification of specific IgE ...

Allergy during anaesthesia is an important health problem with a significant mortality and morbidity. Unfortunately, correct diagnosis is not always straightforward and too frequently overlooked. Thereby placing the patients at unnecessary risk for future life-threatening reactions. Uncertainties associated with skin testing with some of these drugs, and the general unavailability of drug-specific immunoglobulin E tests contribute to the ...

Drug hypersensitivity constitutes a significant health problem with serious consequences of both mis- and overdiagnosis. nfortunately, correct diagnosis of drug hypersensitivity can pose significant challenges, mainly because of our knowledge gaps in the molecular and pathophysiological processes underlying immediate and non-immediate drug hypersensitivity reactions but also, most importantly, because of the unavailability of reliable in vitro ...

The Research Consortium of Excellence Infla-Med combines multidisciplinary expertise of eight research groups from two faculties to perform fundamental and translational research on inflammation, including: inflammatory gastrointestinal, cardiovascular, lung and kidney disorders, sepsis and allergies, as well as parasitic diseases, thereby focusing on specific inflammatory cell populations, including monocytes/macrophages, mast cells, basophils ...