Mechanisms and Diagnosis of Mast Cell and Basophil Activation in Rare Hypersensitivity Disorders KU Leuven
Hypersensitivity is an exaggerated response of the immune system to harmless triggers. In Type I hypersensitivity or allergy, effector cells (mast cells and basophils) are activated through allergen-induced cross-linking of surface-bound allergen-specific IgE antibodies, leading to degranulation and systemic release of inflammatory mediators. This can result in a potentially life-threatening rapid-onset clinical syndrome affecting the ...