Projects
A role for B cells in immunomodulatory treatment of multiple sclerosis. KU Leuven
Impact of early-life multi-mycotoxin exposure on B cells epigenetic profile and infection by oncogenic viruses: unravelling interaction with immune-regulatory cytokines profiles & co-infections in young children Ghent University
Oncogenic viruses play an essential role in carcinogenesis. Chronic dietary intakes of multiple mycotoxins are hypothesized to be associated and interact with these viruses to enhance the risk of developing juvenile carcinomas. In this proposal we focus on infection by the Eppstein-Barr virus (EBV), which is linked to childhood Burkitt’s lymphoma, and endemic in parts of sub-Saharan Africa, where EBV and chronic mycotoxin exposure co-exist. ...
SRP-Groeifinanciering: Unravelling the host-parasite interactions that result in B cell destruction during trypanosomosis and development of novel intervention strategies focusing on diagnosis and anti B cell cancer therapy Vrije Universiteit Brussel
Hepatitis B-specific B cells: Rehabilitating the B in HBV. University of Antwerp
Unraveling the structural and functional roles of THEMIS proteins in T cell and B cell development and inflammation Ghent University
The human immune system is a sophisticated defense mechanism which identifies invading pathogens and molecular challenges to coordinate their neutralization and removal Specialized cells known as T and B lymphocytes are key effectors of the adaptive immune response Lymphocyte development is tightly controlled to prevent the expansion of destructive, self-reactive T and B cells and the development of autoimmune diseases Themis1 and Themis2, ...
Validation of a new mouse model of systemic sclerosis and study of the B cell as effector cell in the disease Ghent University
The purpose of this project is to examine the role of the TNF cytokine, lymphotoxin, in the pathogenesis of systemic sclerosis, especially its role on B cells.
An on-chip single B cell mining platform for rapid development of fully human therapeutic antibodies and for immunoprofiling human antibody responses KU Leuven
Endoplasmic reticulum and mitochondria: common drivers of human β cell and neuronal fate KU Leuven
Diabetes and brain disorders appear at first glance to be completely different diseases. However, human
genetics has unveiled some severe forms of diabetes in babies that are associated with abnormal brain
development, including small brain size and epilepsy. Intriguingly, the mutations causing these diseases hit
genes with a role in two critical organelles: the endoplasmic reticulum and mitochondria, which together control ...
Unraveling the molecular signal pathways that govern parasite- induced B cell killing for the development of new immunological strategies in the fight against lymphoma diseases Vrije Universiteit Brussel
myeloma plasmacytoma development. Our research hypothesis is that we can 'use' these parasite activities (not the parasite itself) in future ...