T-bet induced age-associated B cells contribute to multiple sclerosis pathology and progression Hasselt University
In autoimmune diseases, the immune system aberrantly targets self-tissues, such as the central nervous system in multiple sclerosis (MS). B cells are important immune cells contributing to MS pathogenesis by the production of antibodies that mark self-antigens for immune mediated destruction, by stimulating T cell responses and by producing immunological mediators (cytokines). A proportion of MS patients have characteristics of an aged immune ...