Characterization and validation of novel autophagy inducers identified via high-throughput screening: a therapeutic option for the treatment of advanced atherosclerosis. University of Antwerp
Autophagy is a highly conserved intracellular recycling process that removes unnecessary or dysfunctional cellular components from the cytoplasm. Defective autophagy is a main feature of several human pathologies such as neurodegeneration, cancer and cardiovascular disease. Accordingly, there is strong interest in pharmacological agents that stimulate autophagy. Yet, the unequivocal validation of autophagy induction as a therapeutic strategy is ...