Projects
Investigating the role of autophagy in arterial calcification and arterial stiffness. University of Antwerp
Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy Ghent University
Autophagy is crucial in the (patho)physiology, including inflammation, infection and cancer. Autophagy functions as a survival mechanism by maintaining viability during periods of stress, and by removing damaged organelles and toxic metabolites, such as protein aggregates or intracellular pathogens. The Atlantis research consortium (AuTophagy in InfLAmmatioN and inflammaTory dISorders) brings together a team of expert investigators from the ...
Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy. KU Leuven
Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy. University of Antwerp
Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basicinsights to experimental therapy. University of Antwerp
Development of an in vivo autophagy modulation model of the rat liver using adeno-associated virus-mediated delivery of shRNA KU Leuven
Recovery from critical illness: role of autophagy and epigenetics. KU Leuven
The development of critical care medicine over the last 50 years allowed patients to survive acute life-threatening conditions. Whereas most of these patients recover within a few days, a substantial number of critically ill patients develop multiple organ failure (MOF), which prolongs the dependency on intensive care and increases health care costs. Despite major advances in intensive medical care, MOF is still a leading cause of morbidity ...
The role of lysosomal Ca2+ in the regulation of autophagy KU Leuven
The ER is the largest organelle found in the cell and acts as the largest Ca2+ store, with a [Ca2+]ER around 500 µM while the [Ca2+]cyt is around 100 nM. Various proteins, including the SERCA pump and the IP3 receptor, regulate the Ca2+ content of the ER. The high [Ca2+]ER is important for the role of Ca2+ as second messenger, but also for the proper functioning of the ER chaperones involved in the folding of newly synthesised proteins and in ...