Moving upstream of DOT1L activity and H3K79 methylation to safeguard the articular cartilage KU Leuven
Osteoarthritis is the most common chronic joint disease with enormous societal costs. In osteoarthritis, structure and function of the joints are gradually affected leading to pain and disability. Current treatment options remain limited and no drug strategies are available that can stop the progression disease. We have contributed to the discovery that DOT1L, an enzyme that modulates gene expression in the cell nucleus, plays a role in this ...