Projects
Towards modelling the human colon microbiota dynamics: an applied systems biology approach Vrije Universiteit Brussel
Large-intestinal hydrogen production affects both colon ecosystem stability ...
Towards modelling the human colon microbiota dynamics: an applied systems biology approach KU Leuven
In spite of the importance of the gastrointestinal microbiota in health and disease, interactions between key groups of colon microorganisms are underexplored. Quantitative data, enabling dynamic model development, is currently lacking. The present project proposes to explore the dynamics of a simplified human intestinal microbiota in vitro and in silico.
Large-intestinal hydrogen production affects both colon ...
applied vegetation ecology Ghent University
A BOF-ZAP-mandate holder receives an appointment or appointment as a member of the Independent Academic Personnel with mainly research assignment. The wage costs are charged to the resources of the BOF.
Towards Individualised Model-based Monitoring: From Biology to Technology KU Leuven
One of the main obstacles in applying engineering approaches to biological processes remains dealing with inter- and intra-individual differences. Therefore, it is highly challenging to accurately monitor their individual state (cfr. personalised medicine). The general objective of this PhD is to develop a framework for individualised model-based monitoring for biological processes, as inspired by control engineering concepts. The presented ...
SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics Ghent University
The novel single-cell technologies allow to determine the genetic profile of each individual cell per organ. This way, researchers have recently identified novel cell types and activation states that correlate with disease progression or specific developmental stages. However, these techniques are carried out on digested tissue samples and don’t give any information on the precise location of cells. Unfortunately, to fully understand how ...
Unlocking powerful non-model organisms in microbial synthetic biology - POSSIBL. University of Antwerp
FABLITE – A light sheet microscopy and microfabrication 'ménage-à deux' for real-time, high throughput and physiological structural biology. Hasselt University
Integrating a novel layer of synthetic biology tools in Pseudomonas, inspired by bacterial viruses KU Leuven
As nature’s first bioengineers, bacteriophages have evolved to modify, adapt and control their bacterial hosts through billions of years of interactions. Indeed, like modern synthetic biologists aspire to do, bacteriophages already evade bacterial silencing of their xenogeneic DNA, subvert host gene expression, and co-opt both the central and peripheral metabolisms of their hosts. Studying these key insights from a molecular systems biology ...
Disclosing thermophiles for industrial biotechnology by developing an orthogonal synthetic biology toolbox. Ghent University
Over the past decades, the development of microbial cell factories for industrial applications was limited by the over-reliance on non-optimal model organisms. These non-optimal hosts are applied in bioproduction processes or for bioengineering. However, typically cell resources are used inefficiently, and there is a toxic build-up of intermediates, causing a metabolic burden and leading to lower yields and suboptimal processes. Indeed, a ...