MAPPING OF ANTIVIRAL TARGETS IN THE ALPHAVIRUS PROTEOME AND ESTABLISHMENT OF RELEVANT INFECTION MODELS TO ASSESS ANTIVIRAL EFFECTS KU Leuven
Alphaviruses cause severe diseases such as encephalitis and arthritis. Some alphaviruses, including
the chikungunya virus (CHIKV), are significant global health threats because of their high disease
burden, their (re-)emergence, and the lack of vaccines or therapeutics. In this research proposal
we aim to identify new druggable targets in the replication cycle of alphaviruses by a
chemobiology approach. The study of these ...