Projects
MulTplex project: Development of a combinatorial multi-epitope T-cell receptor (TCR), non-signaling chimeric antigen receptor (NSCAR) and immunosuppressive immune checkpoint (IICP)-disrupted adoptive T-cell therapy against leukemia. University of Antwerp
Preclinical development of novel chimeric antigen receptor (CAR)-modified cell-based immunotherapy approaches for hematological malignancies. University of Antwerp
Evaluation of a novel hinge and co-stimulatory domain in BCMA-targeted chimeric antigen receptor T cells. University of Antwerp
Exploration of differentiated iPSCs as peptide antigen source for tolerizing immunizations in autoimmune disease Ghent University
Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the central (CNS) nervous system. While its etiology remains unknown, it is considered to be the result of an auto-inflammatory reaction targeting oligodendrocytes (ODCs), the myelin producing cells of the CNS. Current approved therapies rely on general immunosuppression, leading to a wide range of side effects. Evidence in experimental autoimmune ...
SRP-Onderzoekszwaartepunt: PACT: multi-omics Profiling of T cells to improve Adoptive Cell Therapy Vrije Universiteit Brussel
Biological characterization of autoantibodies associated with therapy response in rheumatoid arthritis Hasselt University
PrioriTCR - Prioritization of T-cell receptors for development of T-cell therapy using an immunoinformatics approach. University of Antwerp
Process monitoring and controlled biomanufacturing of human periosteum derived progenitor cells for cell therapy applications KU Leuven
Cell-based products are an important innovation on the pharmaceutical market. These advanced therapy medicinal products are able to regenerate defects or treat diseases, where other pharmaceuticals fail or only treat the symptoms instead of the disease. The applications of such cell-based therapies vary between treating cancer with chimeric antigen receptor T-cell therapy and regenerating cartilage or bone defects with a cell-based tissue ...