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A qualitative evaluation of the process of creating and implementing an interprofessional care pathway for patients treated with oral anticancer drugs Ghent University KU Leuven
Purpose: To investigate factors affecting the co-creation and implementation of care pathways for patients treated with oral anticancer drugs. Methods: An explorative qualitative process evaluation was performed at four Belgian hospitals, co-creating and implementing a care pathway for patients on oral anticancer drugs. Semistructured interviews and focus groups were performed by a) local coordinators leading an interprofessional project team ...
Patient-centered care coordination, education and counseling of patients treated with oral anticancer drugs : an importance-performance analysis Ghent University KU Leuven
Purpose: To analyse the importance and performance of key elements in patient-centered care coordination, education and counseling of patients treated with oral anticancer drugs. Method: In four Belgian non-academic hospitals, the importance and performance of a set of 82 key elements was cross-sectionally evaluated by primary and secondary healthcare professionals and by patients. These key elements were divided in 6 themes: coordination of ...
Key elements for the education and counselling of patients treated with oral anticancer drugs Ghent University KU Leuven
Purpose: The process of education and counselling of patients treated with oral anticancer drugs, aimed to achieve adequate self-management, involves different stakeholders (Le. physicians, oncology nurses, pharmacists) from primary and secondary care. However, currently no guiding principles exist on how to organize and perform education and counselling for these patients. Therefore, the purpose of this study was to develop and build consensus ...
Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine Hasselt University KU Leuven
The intracellular metabolism and cytostatic activity of the anticancer drug gemcitabine (2′,2′-difluoro-2′-deoxycytidine; dFdC) was severely compromised in Mycoplasma hyorhinis-infected tumor cell cultures. Pronounced deamination of dFdC to its less cytostatic metabolite 2′,2′-difluoro-2′-deoxyuridine was observed, both in cell extracts and spent culture medium (i.e. tumor cell-free but mycoplasma-containing) of mycoplasma-infected tumor cells. ...
Design of new potent and selective thiophene-based K(V)1.3 inhibitors and their potential for anticancer activity Ghent University KU Leuven University of Antwerp
Simple Summary In this article, we describe the discovery of a new class of potent and selective thiophene-based inhibitors of the voltage-gated potassium channel K(V)1.3 and their potential to induce apoptosis and inhibit proliferation. The K(V)1.3 channel has only recently emerged as a molecular target in cancer therapy. The most potent K(V)1.3 inhibitor 44 had an IC50 K(V)1.3 value of 470 nM (oocytes) and 950 nM (Ltk(-) cells) and appropriate ...
Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment Vrije Universiteit Brussel
INTRODUCTION: Since the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a ...
The cocreation of care pathways for patients treated with oral anticancer drugs : from assessment data to an actual care pathway Ghent University KU Leuven
Rationale: Due to the emergence of oral anticancer therapies, existing care processes in oncology – that are mainly focused on in‐hospital treatments – must be rethought. The development of a care pathway is a well‐known methodology to reorganise and standardise care for a specific patient group. However, care pathway development might be complex and burdensome for healthcare teams, requiring a well‐thought‐out methodology that provides guidance ...
Perspectives on seamless collaboration between primary and secondary care for oral anticancer treatments Ghent University KU Leuven
Patients who take oral anticancer drugs (OACD) alternate between the hospital and the community setting. Little is known about how general practitioners (GPs) and community pharmacists (CPs) from primary care (PC) can be involved in providing seamless care. In an exploratory qualitative study, semi-structured interviews with healthcare professionals from primary and secondary care (SC) and (N = 26) were performed to investigate perceptions of ...