Discovery and mechanism of action of novel hEag1 potassium channel lead molecules with anti-cancer activity. KU Leuven
Cancer remains an important cause of mortality and economic losses worldwide. For an improved cancer therapy, a permanent need for the discovery of new-generation, refined anticancer agents is needed. Exploitation of genuinely novel classes of cancer targets with new mechanisms of action provides great opportunities for the discovery of new anticancer drugs. Targeting the voltage-gated potassium channel hEag1 in cancer is one of the most ...