Publications
Autoantibodies neutralizing type I IFNs are present in similar to 4% of uninfected individuals over 70 years old and account for similar to 20% of COVID-19 deaths KU Leuven Ghent University
Neutralizing antibody patterns in sera of individuals infected with human immunodeficiency virus (HIV) type 1, HIV-2 and simian immunodeficiency virus (SIVcpz) to their homologous and heterologous isolates Institute of Tropical Medicine
Nanobodies as novel therapeutic agents in envenomation Vrije Universiteit Brussel
Background: An effective therapy against envenoming should be a priority in view of the high number scorpion stings and snakebites. Serum therapy is still widely applied to treat the envenomation victims; however this approach suffers from several shortcomings. The employment of monoclonal antibodies might be an outcome as these molecules are at the core of a variety of applications from protein structure determination to cancer treatment. ...
Pathogenic CD8+ T cells cause increased levels of VEGF-A in experimental malaria-associated acute respiratory distress syndrome, but therapeutic VEGFR inhibition is not effective Institute of Tropical Medicine KU Leuven
Malaria is a severe disease and kills over 400,000 people each year. Malarial complications are the main cause of death and include cerebral malaria and malaria-associated acute respiratory distress syndrome (MA-ARDS). Despite antimalarial treatment, lethality rates of MA-ARDS are still between 20 and 80%. Patients develop pulmonary edema with hemorrhages and leukocyte extravasation in the lungs. The vascular endothelial growth factor-A ...
Changing receptor use of PRRSV leads to different virological, immunological and clinical outcome: impact on diagnosis and control Ghent University
Characterization of a hepatitis C virus-like particle vaccine produced in a human hepatocyte-derived cell line Institute of Tropical Medicine Ghent University
An effective immune response against hepatitis C virus (HCV) requires the early development of multi-specific class 1 CD8+ and class II CD4+ T-cells together with broad neutralizing antibody responses. We have produced mammalian-cell-derived HCV virus-like particles (VLPs) incorporating core, E1 and E2 of HCV genotype 1a to produce such immune responses. Here we describe the biochemical and morphological characterization of the HCV VLPs and ...