Projects
Characterization and hazard identification of substandard and falsified antimicrobial drugs KU Leuven
According to the World Health Organization (WHO), a counterfeit medicine is defined as follows: “A counterfeit medicine is one which is deliberately and fraudulently mislabelled with respect to identity and/or source. Counterfeiting can apply to both branded and generic products and counterfeit products may include products with the correct ingredients or with the wrong ingredients, without active ingredients, with insufficient active ...
Molecular elucidation of the evolutionary success of Salmonella Kentucky ST198 KU Leuven
Salmonella enterica serovar Kentucky (S. Kentucky) is a common cause of gastro-enteritis. Although resistance to critically important antibiotics for human medicine is rare among Salmonella species, the clonal variant S. Kentucky ST198 poses an exemption. Phylogeographic analysis indicates this clone first emerged in Egypt around 1989, before disseminating into Northern, Southern and Western Africa, and then further to the Middle East, Asia ...
Molecular elucidation of the evolutionary success of salmonella Kentucky ST198 KU Leuven
Salmonella enterica serovar Kentucky (S. Kentucky) is a common cause of gastro-enteritis. Although resistance to critically important antibiotics for human medicine is rare among Salmonella species, the clonal variant S. Kentucky ST198 poses an exemption. Phylogeographic analysis indicates this clone first emerged in Egypt around 1989, before disseminating into Northern, Southern and Western Africa, and then further to the Middle East, Asia ...
Disaster Governance: Analyzing inconvenient realities and chances for resilience and sustainability KU Leuven
English summary
Disaster governance
Analyzing inconvenient realities and chances for resilience and sustainability
A social-ecological systems approach to disaster governance
In many places in the world, people are increasingly exposed to disasters. A few recent disasters illustrate the global magnitude of the problem: the oil spill in the Gulf of Mexico in 2010, the earthquake, tsunami and ...
Synthesis and biological evaluation of C-nucleoside analogues KU Leuven
C-Nucleosides are an important family of compounds with promising biological activities. In C-nucleosides, the labile C-N glycosidic linkage of classical N-nucleosides is replaced by a more stable C-C bond, which makes C-nucleosides resistant against hydrolysis. Some naturally occurring C-nucleosides such as formycin and showdomycin are potent antibiotics, while pseudouridine, an isomer of uridine, is able to stabilize RNA duplexes by ...
Development of Artificial Genetic Systems for Therapeutic Applications KU Leuven
Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are among the most remarkable biomolecules occurring in nature, since they store and transfer all genetic information using only four letters (G, C, A & T or U). In the last 60 years, since the discovery of the structure of nucleic acids, numerous chemically modified nucleosides and nucleotides have been produced and incorporated into oligomeric sequences either by chemical or ...